Aquaporins are specialised proteins embedded in cell membranes that act as channels for water transport. They regulate water flow in and out of cells, playing a crucial role in maintaining skin hydration at a cellular level. Beyond water, some aquaporins also facilitate the movement of glycerol and small solutes, which are essential for skin metabolism and barrier function. For practitioners, recognising the function of aquaporins is essential: optimal activity contributes to plump, resilient skin, while reduced function is linked with dryness, fine lines and impaired barrier repair.

In the skin, aquaporin-3 (AQP3) is particularly important. It helps transport water and glycerol, which are fundamental for maintaining elasticity and moisture balance. Research indicates that enhancing AQP3 expression can improve hydration, accelerate wound healing and support a healthy barrier function.

Aesthetic professionals can supplement conventional procedures with treatments that support aquaporin function, such as topical moisturisers or dietary interventions, to achieve more sustained improvements in skin texture and appearance.

Plant-based diets are rich in polyphenols, vitamins and minerals that influence aquaporin activity. For instance, flavonoids found in berries, leafy greens and colourful vegetables have been shown to support cellular hydration pathways. Additionally, adequate intake of water-rich plant foods, such as cucumbers, watermelon and citrus fruits, provides both hydration and nutrients that facilitate aquaporin efficiency.

Omega-3 fatty acids from flaxseeds, chia and walnuts can support skin barrier integrity, indirectly benefiting aquaporin-mediated water transport. Practitioners can encourage clients to adopt dietary patterns that prioritise whole, plant-based foods to naturally enhance skin hydration and resilience.

Incorporating knowledge of aquaporins into skincare routines and nutritional counselling provides a holistic approach to skin health. Topical formulations containing humectants like glycerin, hyaluronic acid and botanical extracts may upregulate AQP3, enhancing water retention in the epidermis. Meanwhile, nutrition strategies can ensure that cells have the building blocks needed for optimal aquaporin function.

By combining aesthetic treatments with plant-forward nutrition, practitioners can offer clients evidence-based recommendations that not only improve skin appearance but also support long-term cellular hydration and barrier function.

Aquaporins are more than microscopic channels, they are integral to skin vitality, hydration and resilience. For professionals in aesthetics, dermatology and nutrition, understanding and supporting aquaporin function opens a pathway to more effective, sustainable outcomes. Encouraging plant-based dietary patterns, topical hydration strategies and lifestyle practices that nurture these proteins can transform the way we approach skin health.