A complementary perspective is offered by Tomas et al. (2025), who reviewed the mechanisms by which plant-based phytochemicals exert anti-aging effects. Their findings emphasize carotenoids, polyphenols, and flavonoids as key molecules in protecting skin from oxidative stress, improving mitochondrial function, and preserving extracellular matrix integrity. Importantly, they underscore the role of both dietary intake and topical application of these phytochemicals for maximum benefit.

Das et al. (2024) broaden the lens by examining traditional plant-based diets (e.g., Mediterranean, Asian, and indigenous diets) and their contribution to healthy aging and skin vitality. These diets, rich in fermented foods, legumes, fruits, and vegetables, contain bioactive compounds that reduce chronic inflammation, a major contributor to skin aging. The paper suggests that long-term dietary patterns, rather than isolated supplements, may be more impactful in promoting youthful longevity.

Xie et al. (2024) analyzed plant extracts used in natural cosmetics, identifying compounds that activate cellular anti-aging pathways such as Nrf2 and SIRT1. The authors advocate for integrating botanicals into skincare routines as a safer and sustainable alternative to synthetic compounds, with less irritation and long-term benefits.

Banjerdpongchai & Suttajit (2023) explore the global rise in plant-based diets linked to anti-aging benefits. Their chapter reviews how centenarian populations across continents often share common dietary patterns rich in plants, low in animal fat, and abundant in antioxidants. They highlight the cross-cultural convergence on plant-based eating as a key longevity and beauty factor.

Nobile et al. (2023) conducted a randomized, double-blind clinical trial testing a four-plant blend. The formulation, when taken as a dietary supplement, demonstrated significant improvements in wrinkle reduction, hydration, and collagen density over 12 weeks. This study bridges the gap between in vitro promise and human efficacy, making a strong case for plant-based nutraceuticals.

Lastly, Knaggs & Lephart (2023) focus on how a whole-food plant-based diet (WFPD), when combined with other healthy lifestyle choices (like physical activity and sleep), optimizes skin health outcomes. They specifically address young adults, showing that early adoption of such diets supports long-term skin integrity and prevents premature aging.

This emerging body of research strongly supports the multimodal benefits of plant-based interventions—both topical and dietary—in promoting skin health and delaying aging. While the mechanisms vary (antioxidant action, anti-inflammatory pathways, mitochondrial support), the common denominator is the bioactive richness of plants. Together, these studies make a compelling case for further clinical trials, particularly long-term, multi-ethnic studies, to validate these effects across diverse populations.