Treatment with estrogen will help in morphological modification such as increasing the number of  glycosaminoglycans and fibroblasts. It  not only helps with altering the effects of declining estrogen but arrests the later effects.Some of these plant chemicals, such as phytoestrogens were shown to confer significant long-term health benefits.Phytoestrogens are structurally and functionally similar to human estrogen. There are two types of phytoestrogens, the lignans and the isoflavones.

Isoflavones exhibit biological activities similar to estrogen with structural similarities to both natural and synthetic estrogen.Isoflavones, naturally present in plant sources such as  soybean. They mimic  human estrogen due to their structural resemblance , enabling them to interact with estradiol receptors.They contain the isoflavones genistein and daidzen.Isofavones, particularly genistein, have a higher affinity for the beta subtype of the estrogen receptor present in skin.Among these, equol, the final product of diadzein biotransformation,has clear estrogen-like activity and displays affinity for both the alpha and beta estrogen receptors.