Fibroblasts are specialised cells of the connective tissue responsible for synthesising and maintaining the extracellular matrix (ECM). They produce key structural proteins such as collagen, elastin, and fibronectin, which form the skin’s supportive framework. During collagen biosynthesis, fibroblasts assemble pro-collagen within the cell, secrete it into the ECM, and guide its transformation into mature collagen fibrils. Fibroblast activity declines with age and oxidative stress, resulting in reduced collagen production and visible skin ageing though nutrition, antioxidants, and certain plant compounds can help support their function.